Both of the studies above did not correlate serum AMH, AFC and FSH as markers of ovarian reserves. The mean of age was similar to that in the current study, although the median was lower than our value. (2011) also studied serum AMH related to women’s ages with a total sample of 17.120 women who came to an infertility center in the United States. Chronological age is simply how long an individual has lived in years, months, days, or a combination of all of these (e.g. This difference might be caused by several factors, including different populations with different genetic and environmental backgrounds, which could lead to a different ovarian biological age compared to chronological age. (2011) with 9.601 infertile women showed that serum AMH will decrease with age and found that serum AMH in all percentiles were lower compared to our study. Our previous study showed that serum AMH has a cut-off value of 1.4 ng/ml for predicting poor responders. This difference might be caused by a few of the subjects of this particular age being PCOS patients and thus might not represent the general population. It was generally found that serum AMH levels decreased in a linear fashion, although there was a slight different result in the 90th and 97th percentiles, where an increase in serum AMH among 22- to 24-year-old women was noted on both percentiles. studied the female Indonesian population and found that 8 antral follicles is the cut-off value for determining a poor responder.įigure 2b illustrates the linear correlation of serum AMH levels with age. Many genetic and environmental factors that influence follicle loss have also not yet been identified. Biological age is also a much more reliable indication of a person’s current health than chronological ageso if you haven’t been paying any attention to it (or didn’t even know it was a thing), it’s time to start. These differences show that the mechanism of follicle loss has not yet been well described. The discrepancy between the DNA methylation age and chronological age can be used to determine a measure of age acceleration. The key difference between chronological age and biological age is that you can actually change the latter. found a bi-exponential decrease of AFC at the 4th decade of a woman’s life, representing an accelerated follicle loss. Their study found a similar linear biphasic correlation however, each percentile had a different switching age, as in the lower percentile groups the acceleration of AFC loss started at a younger age.
These findings are slightly different from the results of a study with 1.866 samples by Almog et al.
It was found that the decreasing pattern is quite similar for all percentiles, with 33 years old considered the switching age. The graph shows a relatively flat AFC loss at younger ages, followed by a faster decrease in the number of follicles after a certain age, which is called a “switching age”. Figure 2a shows a linear biphasic correlation between AFC and age.
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